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KMID : 0604519980240030031
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Journal of the Society of Cosmetic Scientists of Korea
1998 Volume.24 No. 3 p.31 ~ p.37
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EFFECT OF KOREAN BLACK SOYBEAN SEED ON THE CELLULAR PROLIFERATION AND THE PRODUCTION OF TYPE 111 COLLAGEN IN SKIN FIBROBLAST
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Lee Choong-Won
Pyo Hyeong-Bae
Cho Young-Ho
Park Seong-Min
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Abstract
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Soybeans are one of the major crops for human food resource; protein, lipid, and carbohydrate. In these days, they are widely using for cosmetics to supply phospholipid; natural surfactant. In this study we used black soybean seed in korea and observed many kinds of biochemical constituents; isoflavone, melatonin, crisantemine and calcium in ethanol extract. Also, its extract (we named it Flatonin) has been demonstrated that korean black soybean seed is able to stimulate the proliferation of NIH 373 cells and increase the production of type III collagen in NIH 373 and Malme-3 (human skin fibroblast) cells. The addition of korean black soybean to quiescent NIH 373 cells resulted in an increase of proliferation which was assayed by MTF method. The maximum effect of korean black soybean was detected in 0.4％ korean black soybean treated cells which was comparable to that of 5% serum(96％ of 5％ serum effect). The addition of korean black soybean to NIH 373 and Malme-3 cells also increased the production of type III collagen in both cells. These results indicate that korean black soybean may enhance the repair process after injury and prevent aging processes in connective tissues.
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KEYWORD
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